Wimmera police were part of road enforcement campaign Operation Crossroads from Thursday to Easter Monday.

The initiative was a joint operation between Australian and New Zealand police.

The highest speed detected in the Wimmera was 140 kilometres an hour in a 100kmh zone on the Western Highway at Kiata.

Another high speed detected was 130kmh in a 100kmh zone on the Sunraysia Highway.

Horsham Highway Patrol Sergeant Wayne Caddy said there were too many people speeding - a common concern.

"Drivers are in too much of a hurry to get from one point to another," he said.

Police detected 113 speedsters in the Horsham police service area, and another 155 speeding drivers in the Northern Grampians area during Easter.

Officers also detected six drink-drivers in the Wimmera, but no drug-drivers.

Other common offences in the Wimmera included 15 unlicensed drivers, 11 seatbelt offences, 17 unregistered vehicles and seven mobile phone offences.

There were also two car crashes on Wimmera roads during Easter.

A car ran off the Western Highway two kilometres west of Kiata at 4.45am on Easter Monday.

The single vehicle crash involved a man and woman from Melbourne.

Nhill Senior Constable Karyleen Hateley said the car rolled and hit a concrete culvert.

An ambulance crew drove the man and woman to Wimmera Base Hospital for a check-up.

Ambulance Victoria spokeswoman Gabrielle Degenhardt said the male driver broke his leg.

The second crash was also on Monday when a Horsham woman's car ran off the road and hit a tree on the Henty Highway after 4pm.

The single vehicle crash was south of McKenzie Creek bridge.

The female driver, 25, sustained a serious leg injury after her legs became trapped.

State Emergency Service volunteers freed the woman from her car while Horsham police directed traffic around the scene.

Ms Degenhardt said an air ambulance crew flew the woman in a serious but stable condition to The Alfred.

Northern Grampians Acting Inspector Damian Ferrari said roads in the Northern Grampians area were incident-free during Easter.

"This was pleasing, considering it's our busiest time of the year particularly with the Stawell Gift, Great Western Rodeo and Stawell races all on during Easter," he said.

"However, there were still a number of drivers we fined for speeding and other offences."