The Western Highway at Dadswells Bridge has reopened after a truck carrying alcohol and potato crisps spilled its load early on Thursday morning.
Horsham Police Sergeant Michael Salter said the B-Double truck crashed into a safety fence about five kilometres out of Dadswells Bridge, heading towards Stawell.
"It happened a bit after 2.40am," he said.
He said the load - an assortment of alcohol, in bottles and cans, and bags of potato crisps - was strewn everywhere as the truck rolled onto its side.
"There was glass and liquid on the road, which we are very cautious about," Sgt Salter said.
A VicRoads spokesperson said traffic from Horsham to Stawell was diverted onto the Henty Highway, the Wimmera Highway to Rupanyup and the Stawell-Warracknabeal Road through Glenorchy.
Paramedics took the truck's driver, a 32-year-old Melbourne man, to the Stawell District Hospital shortly after the crash.
Sgt Salter said police were still investigating the cause of the incident.