A MIDDLE-AGED driver has been airlifted to The Alfred hospital in Melbourne after his vehicle and a semi-trailer collided on the Western Highway on Tuesday.
Victoria Police Sergeant Kris Hamilton said a Ford Falcon sedan was travelling west when it collided into the side of the semi-trailer heading in the opposite direction at 11.11am.
The crash occurred between Ararat and Beaufort.
Traffic diversions were in place along the stretch of the road, which was closed as emergency services attended.
It has since been reopened.
Sgt Hamilton said an Adelaide couple was travelling in the Ford.
"The middle-aged male driver remained trapped in the vehicle for some time until freed by SES,’’ he said.
"He was then airlifted and taken to the Alfred hospital with non-life threatening injuries."
Sgt Hamilton said the man's passenger, a middle-aged woman, suffered from shock but was otherwise uninjured.
"It appears as though fatigue may have been a contributing factor," he said.
"Northern Grampians Highway Patrol is investigating.’’
The driver of the semi-trailer, who was the vehicle's sole occupant, was shaken but otherwise unharmed.
The Western Highway was closed until about 2pm, with traffic detours in place along the Pyrenees Highway and Sunraysia Highway to Avoca.