UPDATE: A motorcyclist has been flown to the Royal Melbourne Hospital after crashing his bike near Mockinya.
The crash happened on the Henty Highway about 3pm on Sunday.
Ambulance Victoria spokesman John Mullen said the man was in his 40s.
"He was in a serious but stable condition with chest, head and back injuries," he said.
Northern Grampians Highway Patrol also attended a single-car crash at Stuart Mill just before 1pm.
Paramedics assessed and treated a woman, 19, at the scene after she crashed her car into a tree on the Sunraysia Highway.