Emergency services were called to Dimboola-Rainbow Road about 4.30pm on Thursday after a tipper truck with trailer crashed outside the Antwerp cemetery.

The Horsham truck driver, 38, was trapped his vehicle.

He was the sole occupant of the truck.

Horsham Highway Patrol Senior Constable Lee-Anne Birthisel said the crash was caused by a tyre puncture.

"It caused the vehicle to veer across the road and pretty much side-swipe the cemetery fence and some trees," she said.

The truck cabin was crushed.

The trailer it was towing, which was filled with a load of sand, rolled.

Sen Const Birthisel said the man sustained serious lower leg injuries.

He said a helicopter flew the man from the scene to Horsham, before he was air-lifted to Royal Melbourne Hospital.

He remains in a stable condition.

Power was disconnected in nearby Jeparit and Antwerp for about an hour as a crane removed the vehicle.

GWMWater was also in attendance after the truck ran over one of the water mains, causing it to rupture.

The scene was cleared about 10.30pm.