OUYEN United can stake a claim for third spot on the ladder when it hosts Woomelang-Lascelles at Ouyen Recreation Reserve on Saturday.
But the fourth-placed Demons will have to achieve something they have failed to do this season - beat a team above them on the ladder.
The Demons have beaten bottom three sides Hopetoun, Jeparit-Rainbow and Walpeup-Underbool comfortably, but have suffered defeats at the hands of Sea Lake-Nandaly Tigers, Beulah and the Cats.
Forward duo Laurence Angwin, 20 goals, and Brad Vallance, 18, will be pivotal to reversing the 38-point margin from when the two sides met in round one.
However, it will be no easy feat against a Cats side that will look to bounce back from a 54-point loss to the Tigers at the weekend.
The Cats and the league's two leading goal-kickers - Jayden Lonergan and Corey Kelly - were held to just three goals between them.
Beulah returns from a bye to face the side it is currently in merger discussions with - Hopetoun - at home.
The ladder-leading Blues enjoyed a 20-goal win last time the two sides met, boasting six multiple goal-scorers.
One of those players, Denis Redden, is yet to be held to less than three goals in a game this season.
Redden has received support from a potent forward line featuring the likes of Shaun Monohan and Brock Orval.
Key to Hopetoun's chances of causing an upset will be the availability of VFL-listed midfield star Coleman Schache, who has turned in three best-on-ground performances for the Devils in four games.
The second-placed Sea Lake-Nandaly Tigers will host Walpeup-Underbool as they chase their third successive win.
Cliff and Darcy Ryan were instrumental in the Tigers' big win over the Cats at the weekend, and both will again be important to the host's plans.
The Roos will enter the match confident after a breakthrough win at the weekend against Jeparit-Rainbow, but will face a mighty challenge.
Roos star David Piasente made his return from injury and was among his side's best, just as he was in round one when the Tigers won by five goals.