UPDATE: The Western Highway has been re-opened between Beaufort and Middle Creek.
The highway was closed after a truck rolled over about 5am.
A VicRoads spokeswoman said the road re-opened and detours were lifted at 2.48pm.
THE Western Highway is closed between Beaufort and Middle Creek because of a truck roll over.
Emergency services are on scene.
Traffic is being diverted to the Sunraysia Highway to Avoca, then the Pyrenees Highway.
Victoria Police Sergeant Kris Hamilton said the road was likely to be closed until about 5pm.
He said the B-Double, which was carrying a load of fresh pork, rolled at Middle Creek about 5am.
It was the only vehicle involved in the incident.
"The truck was travelling east-bound towards Ballarat when it crashed," he said.
"It was going around a left-hand verge in the road when the driver lost control.
"The truck veered down an embankment and back onto the road.
"The driver suffered a few minor injuries, but nothing significant."