The Horsham Saints are striving to claim a third straight A Grade premiership in the Wimmera league.
But several new coaching appointments will have teams confident of chasing the reigning premiers down as the new season starts this weekend.
Long-time Wimmera netball coach Gayle Leith believes the Horsham Saints remain the benchmark, but are vulnerable with a changing line-up.
"I think, at the moment, everyone will be looking at the Horsham Saints to compare themselves - but it's really hard when they haven't got all their players every week to play against," she said.
"Though I wouldn't write them off, by no means.
"You could never write them off."
The Horsham Saints will likely miss star sisters, Maggie and Rene Caris, at stages of the season due to other sporting commitments.
Horsham will hope to return strongly under new coaching pair Mel Scott and Amanda Worth, after last season's heartbreaking grand final loss.
Wimmera Netball Association president Amanda Cole said the Demons were a team to watch.
"Horsham is always strong. I have heard on the grapevine that they have had some changes to their line-up, but they always seem to be able to attract either new quality players or bringing up their juniors," she said.
Warrack Eagles lost Zandria Malone to the Horsham District league, but last season's minor premiers are confident a steady side and hard work will help them better last season's semi-final loss.
Billie Bibby, 23, will take the reins of Minyip-Murtoa this season and becomes one of the youngest A Grade coaches in the region.
"It will be interesting to see how it all goes with her as coach and with their new recruits. They have some handy pick-ups, and they're a nice, young team," Leith said.
The Burras welcomed Edenhope-Apsley A Grade pair Alex Lang and Rachel Elmslie in the off-season.
Leith picked Ararat as outside contenders, with the club fielding a blend of experience and young talent.
"To have someone like a five-time Hatcher Medallist in Megan Shea, just her presence to walk on out the court gives her team so much confidence," she said.
Dimboola split the coaching role in the off-season, with Danni Taylor stepping up to join Jodie Hayes as co-coach.
Southern Mallee Giants and Stawell are two clubs hoping to improve.
The Giants have new coaches in Janelle Lawson and Madde Shannon and are excited about the arrival of Horsham premiership player, Steph Thompson.
Mandy Stephan returns to the A Grade coaching role at Nhill after several years away.
The club has retained core players in the hope of improving on a couple of disappointing seasons.
ARARAT: In - Taylor Mason. Out - Krystal Fisher
DIMBOOLA: In - no major arrivals. Out - Carly Werner (pregnancy), Louisa Vague
HORSHAM: In - Paige Lloyd, Georgia Hiscock, Faith McKenzie. Out - Elley Heard, Penelope Manserra, Sheridan Petering
HORSHAM SAINTS: In - Larnie Hobbs (return from major injury), no major arrivals. Out - Shannon Cross (pregnancy), no major departures
MINYIP-MURTOA: In - Alex Lang, Rachel Elmslie, Taylor Mentha. Out - Stef Cooper, Maddie Morgan
NHILL: In - Mandy Stephan returns as coach, no major arrivals. Out - Jessica Smith, Rosie Smith
WARRACK EAGLES: In- Eilish Flagg. Out - Zandria Malone
SOUTHERN MALLEE GIANTS: In - Steph Thompson, Amy Dodd, Marnie Lehmann. Out - Ruby Fisher, Zoe Turnbull
STAWELL: In - Hannah Parker. Out - Sarah Morris