The state government opened registration for 40,000 travel vouchers online at 10am on Friday but the Business Victoria website was replaced with a white page reading "Internal server error".

"Business Victoria is experiencing heavy demand for regional travel vouchers, which has resulted in the application back going offline," a spokesman said in a statement.

"Business Victoria is working to resolve this issue."

Eligible destinations include the Grampians, while households can apply even if their travel has already been booked.

The $28 million travel voucher scheme is part of a $300 million tourism package announced in the state budget in November.

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"If those $200 vouchers mean that people stay an extra night, maybe go to a local pub or restaurant. That's all about wages and spending and investment," Premier Daniel Andrews said.

40,000 more vouchers would be available on January 20 and 40,000 more on March 30.

Grampians Tourism Marc Sleeman said the vouchers were a welcome initiative for the region.

"Especially the three tranches of vouchers," he said.

"We all know right now demand is not our issue. Our region is experiencing great visitation but that second and third round of vouchers will support that demand driving activity in 2021.

"I think we are going to need it."

Mr Sleeman said the scheme also put vouchers into the hands of Victorians to encourage them to travel within the state.

"We know with the opening of the border to the north there will be an appetite to go on a holiday somewhere else," he said.

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"This is going to encourage Victorians to spend money in our state and help the recovery of Victoria."

Mr Sleeman said he had no doubt the Grampians region was at the forefront of recovery across the state.

"There is no other region that's had the rate of growth in visitation and spend than our region up until June this year," he said.

"I know that our brand appeal of big nature and space to breath is extremely appealing.

"We're going to ride that crescendo of recovery for a number of months.

"Going into shoulder period next year, going into winter, is when we will need to make sure we have the appropriate demand for driving activities in place.

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"It will slow down there's no question that we are going through a euphoric period right now where everyone wants to get out and about."

Mr Sleeman said local residents played a critical role in visitor experience across the region.

"There's nothing better than having a local welcoming you and saying g'day," he said.

"I think we do that pretty well in our region."