Paula Gust, who lives 200m from the South Australian border, said the government's travel restrictions on cross-border communities are "tearing families apart".
Mrs Gust's family travels to Naracoorte in South Australia for groceries, medical care and school, which are no longer considered legitimate reasons to enter the state.
"I have decided the only way we can manage is for my daughter Holli and me to move to Naracoorte.
"Holli is going to Seymour College in Adelaide next year and needs to attend orientation days this year.
The South Australian Government announced Wednesday, Victorians living just across the SA border could no longer enter from Friday August 21.
Mrs Gust said due to the road closure, she travels 26 km to take her daughter to the bus stop, which used to be a 1.5 km round trip.
"Holli is currently in year 9 and goes to Naracoorte High School in SA, but will no longer be able to attend." she said.
"We have accepted and complied with our kids being taken off the bus at the border stop every single day to legitimise their travel.
"The kids can't be suffering anymore ... Victorian cross-border kids have been through enough."
Mrs Gust said she can't buy groceries or visit her son Bodhi who lives in SA.
"We are going to have to ask someone in Naracoorte to pick up our groceries and meet us at the border crossing to handover them over," she said.
"My son also lives in SA where he is doing a building apprenticeship, we wouldn't be able to see him anymore after the border change.
"They should be shutting off the regions, not a clean-cut border closure. "
She said her 69-year-old neighbor had skin cancer and couldn't visit her doctor in South Australia.
"Her doctor has told her to go to Horsham, but she is too scared to go there and is in the high-risk age group," she said.
"Just because our address says we live in Victoria, it's not a simple solution to say we can't come to SA.
"Victorian and SA police need to work together and complete individual assessments."
Mrs Gust started the Facebook page Cross Border Call Out on Wednesday, for cross-border residents to express their concerns and to get the attention of local politicians.
"We have had fantastic feedback, and people in Naracoorte consider us an important part of the community," she said.
"I hope the authorities take notice and take the time to read people's comments and their situations."