Teams will be split into two different regions - the six clubs on the west side of Horsham, and six clubs to the east and north of Horsham.

Clubs will play everyone once, and then play the five other teams from their region, to help limit travel.

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The change means clubs far away from each other, such as the Swifts and the newly-introduced Kaniva-Leeor United, will play each other only once.

"The travel factor was always a question and always a concern, but by adjusting the draw, that has certainly reduced that issue a little bit," AFL Wimmera Mallee area mana Muldoon said.

Teams would play 16 rounds across a 19 week season with three league-wide byes.

CHECK OUT THE 2021 HDNFL DRAW

Kaniva-Leeor United will play its first ever Horsham District league at home against Kalkee.

In other opening round fixtures, Rupanyup travels to Natimuk, Jeparit-Rainbow hosts Taylors Lake, Pimpinio is on the road against Harrow-Balmoral, Noradjuha-Quantong plays host to Swifts, and Laharum treks to Edenhope-Apsley.

Supporters have to wait till round six for a grand final re-match between Harrow-Balmoral and Noradjuha-Quantong.

An A Grade grand final re-match comes the following round, when Natimuk hosts Laharum.